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Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center

Abstract: Introduction and aims: Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making. Materials and methods: Patients with HCC that underwent surgery with curative intent at the Hospital Universitario Marqués de Valdecilla, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed. Results: Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality. Conclusions: There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making.

 Fuente: Revista de Gastroenterología de México, 2024, 89, 323-331

 Editorial: Asociación Mexicana de Gastroenterología

 Año de publicación: 2024

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.rgmxen.2022.12.001

 ISSN: 0375-0906

 Url de la publicación: https://doi.org/10.1016/j.rgmxen.2022.12.001

Autoría

MAGADAN ÁLVAREZ, C.

GONZÁLEZ TOLARETXIPI, E.

LOZANO NÁJERA, A.

ENRIQUE TOLEDO MARTINEZ