Abstract: The present study evaluates the effects of vaccination with Brucella melitensis strains Rev 1 AeryCD and Rev 1 on the reproductive system of male goats. Three groups, each of them consisting of 15 six-month-old brucellosis-free male goats, were studied. The first group was vaccinated with the Rev 1 AeryCD strain, the second group received Rev 1 and the third group was inoculated with sterile physiological saline solution. The dose of both strains was of 1 × 109 CFU/ml. Over the course of the five months of this study, three males from each group were euthanized every month. Their reproductive tracts, spleens, and lymph nodes were collected to analyze serology, bacteriologA PCR, histology, and immunohistochemistry. Results show that vaccination with B. melitensis strains Rev 1 AeryCD and Rev 1 does not harm the reproductive system of male goats. Strain B. melitensis Rev 1 AeryCD displayed a lower capacity to colonize the reproductive tract than strain Rev 1, which was attributed to its limited catabolic action toward erythritol.

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