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Abstract: CD5 is a pan-T-cell surface marker and is rarely expressed in diffuse large B-cell lymphoma (DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking in Western countries. In this study by the DLBCL Rituximab-CHOP Consortium, CD5 was expressed in 5.5% of 879 DLBCL patients from Western countries. CD5+ DLBCL was associated with higher frequencies of >1 ECOG performance status, bone marrow involvement, central nervous system relapse, activated B-cell–like subtype, Bcl-2 overexpression, and STAT3 and NF-?B activation, whereas rarely expressed single-stranded DNA-binding protein 2 (SSBP2), CD30 or had MYC mutations. With standard R-CHOP chemotherapy, CD5+ DLBCL patients had significantly worse overall survival (median, 25.3 months vs. not reached, P< .0001) and progression- free survival (median, 21.3 vs. 85.8 months, P< .0001) than CD5– DLBCL patients, which was independent of Bcl-2, STAT3, NF-?B and the International Prognostic Index. Interestingly, SSBP2 expression abolished the prognostic significance of CD5 expression, suggesting a tumor-suppressor role of SSBP2 for CD5 signaling. Gene- expression profiling demonstrated that B-cell receptor signaling dysfunction and microenvironment alterations are the important mechanisms underlying the clinical impact of CD5 expression. This study shows the distinctive clinical and biological features of CD5+ DLBCL patients in Western countries and underscores important pathways with therapeutic implications.
Fuente: Oncotarget, 2015, Vol. 6, No.8, pages 5615-5633
Editorial: Impact Journals
Año de publicación: 2015
Nº de páginas: 19
Tipo de publicación: Artículo de Revista
DOI: 10.18632/oncotarget.3479
ISSN: 1949-2553
Consultar en UCrea Leer publicación
XU-MONETTE, ZIJUN Y.
TU, MEIFENG
JABBAR, KAUSAR J.
CAO, XIN
TZANKOV, ALEXANDAR
VISCO, CARLO
CAI, QINGQING
SANTIAGO MONTES MORENO
AN, YUJI
DYBKAER, KAREN
CHIU, APRIL
ORAZI, ATTILIO
ZU, YOULI
BHAGAT, GOVIND
RICHARDS, KRISTY L.
HSI, ERIC D.
CHOI, WILLIAM W.L.
KRIEKEN, J. HAN VAN
MIGUEL ANGEL PIRIS PINILLA
HUH, JOORYUNG
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