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Abstract: Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+ DLBCL-e) is a molecularly distinct variant of DLBCL, characterized by a monoclonal B-cell proliferation that occurs in patients >50 years of age without a history or clinicopathologic evidence of immunodeficiency. However, patients with EBV+ DLBCL younger than 50-years-old also exist in Western countries. We evaluated the clinicopathologic, immunophenotypic and genetic features in Cacausian patients with EBV+ DLBCL who are =50 years of age and compared this patient group to patients who are >50 years. In patients who are =50 years, less frequent expression of BCL6 and a trend of more frequent expression of CD30 and pSTAT3 were found in patients with EBV+ DLBCL. In patients who are >50 years, common expression of CD30, p50, pSTAT3 and less frequent expression of BCL6 were observed. Older patients also more commonly had a poor performance status (ECOG=2). Comparing EBV+ DLBCL patients in =50 years versus >50 years, both groups had similar clinicopathologic, immunophenotypic and genetic features. Gene expression profiling, microRNA profiling and treatment outcome of the younger patients with EBV+ DLBCL was not distinctive from tumors in older patients. Based on our data, we suggest that the arbitrary age cutoff for EBV+ DLBCL is unnecessary and should be eliminated in the WHO lymphoma classification scheme.
Fuente: Oncotarget. 2015 Jun 10; 6(16): 13933–13945.
Editorial: Impact Journals
Fecha de publicación: 10/06/2015
Nº de páginas: 13
Tipo de publicación: Artículo de Revista
ISSN: 1949-2553
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OK, CHI YOUNG
YE, QING
LI, LING
MANYAM, GANIRAJU C.
DENG, LIJUAN
GOSWAMI, RASHMI R.
WANG, XIAOXIAO
SANTIAGO MONTES MORENO
VISCO, CARLO
TZANKOV, ALEXANDAR
DYBKAER, KAREN
ZHANG, LI
ABRAMSON, JEREMY
SOHANI, ALIYAH R.
CHIU, APRIL
ORAZI, ATTILIO
ZU, YOULI
BHAGAT, GOVIND
MIGUEL ANGEL PIRIS PINILLA
RICHARDS, KRISTY L.
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