Abstract: Purpose: analysing the change in STI incidence among patients on PrEP treatment at tertiary hospital. Methods: Retrospective observational study that included patients who had been on PrEP treatment for at least 6 months. The incidence of STIs was analysed in the year before starting treatment and at 6 months after starting therapy. Epidemiological, clinical and analytical data were collected in the SPSS program. Findings: Fifty-nine subjects were included, with a mean age of 38.7±11.7 years, of whom 98.3% (58/59) were male. The most common types of STIs before and after PrEP are described in Table 1. Inclusion criteria for initiation of PrEP are set out in Table 2. One patient was diagnosed with human immunodeficiency virus (HIV) in the study prior to starting PrEP therapy. The mean follow up time of patients was 19.4±8.4 months. The mean glomerular filtration rate prior to PrEP was 88.6±7.3ml/min/1.73m2 and 6 months after PrEP 86.2±7.9ml/min/1.73m2 (p=0.05). 77.0% (47/61) of subjects had good adherence to treatment and 23% (14/61) acknowledged adherence failures. Among patients with good adherence to PrEP STIs were diagnosed in 22.8% (10/44) and in 33% (4/12) of those with poor adherence (p=0.3). Conclusions: More than half of the patients who started PrEP had a previous STI. Syphilis was the most frequent infection both before and after treatment initiation. There was a trend towards more STIs among patients with poorer adherence to treatment. Glomerular filtration rate worsened significantly after six months of PrEP therapy but with little clinical relevance.

Autoría

Descargar referencia