Abstract: Objective: To evaluate the patterns of cerebral cortical distribution of 11C-PIB in patients with mild cognitive impairment (MCI). Material and methods: The study included 69 patients (37 male, age range 42–79 years) with MCI, sub-classified as 53 with amnestic-MCI (A-MCI), and 16 with non-amnestic-MCI (NA-MCI). Patients underwent 11C-PIB PET/CT scan 60 min after intravenous injection of the radiotracer. A visual analysis of the images was performed by 2 experienced physicians. 11C-PIB-positive studies were considered when gray matter uptake was equal to or greater than white matter. According to the regions involved, 11CPIB- positive studies were classified into A-pattern (predominant retention in frontal, anterior cingulate, lateral temporal, and basal ganglia) and B-pattern (generalized retention). Results: Thirty-nine of the 69 (56%) patients with MCI showed 11C-PIB retention. Of the 53 A-MCI patients, 36 (68%) showed 11C-PIB retention. Eleven out of 36 (30%) positive scans in A-MCI patients showed Apattern, and 25 out of 36 (70%) patients had a B-pattern. Positive 11C-PIB was observed in 3 out of 16 (19%) patients with NA-MCI. Regional distribution in these 3 patients showed A-pattern in 1, and B-pattern in 2 patients. Conclusion: Cortical retention of 11C-PIB was more frequent in A-MCI than in NA-MCI patients, and also B-pattern than A-pattern in the 11C-PIB positive group. The recognition of 11C-PIB distribution patterns allows MCI patients to be classified, and the A-pattern may offer a therapeutic window for potential future treatments.

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