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Patterns of 11C-PIB cerebral retention in mild cognitive impairment patients

Abstract: Objective: To evaluate the patterns of cerebral cortical distribution of 11C-PIB in patients with mild cognitive impairment (MCI). Material and methods: The study included 69 patients (37 male, age range 42–79 years) with MCI, sub-classified as 53 with amnestic-MCI (A-MCI), and 16 with non-amnestic-MCI (NA-MCI). Patients underwent 11C-PIB PET/CT scan 60 min after intravenous injection of the radiotracer. A visual analysis of the images was performed by 2 experienced physicians. 11C-PIB-positive studies were considered when gray matter uptake was equal to or greater than white matter. According to the regions involved, 11CPIB- positive studies were classified into A-pattern (predominant retention in frontal, anterior cingulate, lateral temporal, and basal ganglia) and B-pattern (generalized retention). Results: Thirty-nine of the 69 (56%) patients with MCI showed 11C-PIB retention. Of the 53 A-MCI patients, 36 (68%) showed 11C-PIB retention. Eleven out of 36 (30%) positive scans in A-MCI patients showed Apattern, and 25 out of 36 (70%) patients had a B-pattern. Positive 11C-PIB was observed in 3 out of 16 (19%) patients with NA-MCI. Regional distribution in these 3 patients showed A-pattern in 1, and B-pattern in 2 patients. Conclusion: Cortical retention of 11C-PIB was more frequent in A-MCI than in NA-MCI patients, and also B-pattern than A-pattern in the 11C-PIB positive group. The recognition of 11C-PIB distribution patterns allows MCI patients to be classified, and the A-pattern may offer a therapeutic window for potential future treatments.

 Fuente: Revista Española de Medicina Nuclear e Imagen Molecular, 2016, 35(3), 171-174

 Editorial: Elsevier

 Año de publicación: 2016

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.remn.2015.09.008

 ISSN: 2253-654X,2253-8070,2253-8089

 Url de la publicación: https://doi.org/10.1016/j.remn.2015.09.008

Autoría

BANZO, IGNACIO

JULIO FRANCISCO JIMENEZ BONILLA

Mª ISABEL MARTINEZ RODRIGUEZ

ARCOCHE TORRES, MARÍA DE

BRAVO FERRER, Z.

LAVADO PÉREZ, C.

PASCUAL SANCHEZ JUAN

JIMÉNEZ ALONSO, M.

LÓPEZ DEFILLÓ, J.

JOSE MANUEL CARRIL CARRIL