Abstract: Innovative anticancer treatments continuously require tissue bioengineering models to test novel
therapies. The increasing number of developments based on nanotechnology for cancer therapy or
theragnostics demand simple, reliable, fast and cost-effective cancer in vivo models for preclinical
testing. However, despite the many tumor models available, very few reproduce the complex
intratumoral cell-to-cell interactions as well as the accompanying systemic whole body effects
resulting of the tumor organ metabolic, hormonal or growth factor activities, all having critical
implications in the success of cancer therapies. Here we describe a reliable tumor model that can be
easily reproduced to generate visible solid malignant melanoma tumor organs within a defined period
of 5–10 days recapitulating the tumor stroma that is essential for cancer development. These models
can be easily evaluated in vivo or by anatomo-pathological procedures. This method provides a fast,
reproducible, reliable and cost-effective way to generate solid tumors for in vivo therapy, drug,
nanomaterial or imaging probe evaluation, diagnostic or theragnostic screening and validation.
Autoría: García-Hevia L., Fernández F., Casafont I., Villegas J.C., Fanarraga M.L.,
Fuente: Biomed. Phys. Eng. Express 2 (2016) 035009
Editorial: IOP Publishing
Año de publicación: 2016
Nº de páginas: 9
Tipo de publicación: Artículo de Revista
DOI: 10.1088/2057-1976/2/3/035009
ISSN: 2057-1976