Abstract: Port infrastructures are increasingly exposed to the impacts of compound climate hazards, yet current adaptation strategies often lack the flexibility required to deal with uncertain future conditions. This study presents a novel framework to design flexible adaptation strategies for port infrastructures, integrating compound climate risk assessment with an operational monitoring strategy. The framework identifies key climate drivers and their interactions, evaluates adaptation options, and defines a set of signposts, tipping points, and triggers to inform timely decision-making. The approach is applied to a case study at the Port of Llanes (Spain), demonstrating how adaptation options can be prioritized and adjusted in response to evolving climate risks. Results highlight the relevance of monitoring the combined effects of waves, sea level, and wind to anticipate infrastructure failures and service disruptions. This work offers an actionable methodology that port authorities can integrate into master plans to ensure climate-resilient operations, while providing a scalable tool for other critical coastal infrastructures.