Abstract: Pulmonary hypertension (PH) is a common complication of chronic respiratory diseases (CRD) associated with increased morbidity and mortality. Early and individualized identification of PH in these patients is crucial to better understand the evolution of the disease and to assess the application of therapeutic measures aimed atits control. However,there is no consensus on how to approach the diagnostic process. The scarce scientific evidence in this field justifies the creation of this SEPAR position paper, which aims to become a tool to aid in the diagnosis of PH associated with CRD that facilitates decision making for the benefit of patients and the optimization of resources. A panel of 16 SEPAR experts has identified three critical questions. The answers to these questions were developed by the panel members, who were divided into three groups according to their expertise in the underlying disease in question: chronic obstructive pulmonary disease, interstitial lung disease and obesity hypoventilation syndrome. Prior to the discussion and drafting of the document by each group, a systematic review of the literature was performed according to the guidelines recommended by the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). We generated a schematic proposal adjusted to the characteristics of each disease for the diagnostic approach to PH associated with respiratory disease.

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