Abstract: Introduction: An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDR GAT haplotype is also associated with atherosclerotic disease in RA. Material and Methods: 591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. Results: VDR rs7975232 AA genotype was increased in RA patients with plaques (p ¼ 0.045, OR ¼ 1.46 [1.01e2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p ¼ 0.009, OR ¼ 1.56 [1.09e2.42]). Conclusion: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients.

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