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 Detalle_Publicacion

Vitamin D receptor GATG haplotype association with atherosclerotic disease in patients with rheumatoid arthritis

Abstract: Introduction: An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDR GAT haplotype is also associated with atherosclerotic disease in RA. Material and Methods: 591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. Results: VDR rs7975232 AA genotype was increased in RA patients with plaques (p ¼ 0.045, OR ¼ 1.46 [1.01e2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p ¼ 0.009, OR ¼ 1.56 [1.09e2.42]). Conclusion: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients.

 Autoría: López-Mejías R., Genre F., Remuzgo-Martínez S., Robledo G., Llorca J., Corrales A., González-Juanatey C., Ubilla B., Mijares V., Pina T., Blanco R., Castañeda S., Martín J., González-Gay M.A.,

 Fuente: Atherosclerosis, 2016, 245, 139-142

Editorial: Elsevier

 Año de publicación: 2016

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.atherosclerosis.2015.12.011

ISSN: 0021-9150,1879-1484

Url de la publicación: https://doi.org/10.1016/j.atherosclerosis.2015.12.011

Autoría

LÓPEZ MEJÍAS, RAQUEL

FERNANDA GENRE

REMUZGO MARTÍNEZ, SARA

ROBLEDO, GEMA

FRANCISCO JAVIER LLORCA DIAZ

ALFONSO FERNANDO CORRALES MARTINEZ

CARLOS GONZALEZ JUANATEY

BEGOÑA UBILLA GARCIA

VERONICA MIJARES DIAZ

PINA MURCIA, TRINITARIO

SANTOS CASTAÑEDA SANZ