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Golimumab in refractory uveitis related to spondyloarthritis. Multicenter study of 15 patients

Abstract: Objective: To assess the efficacy of golimumab (GLM) in refractory uveitis associated to spondyloarthritis (SpA). Methods: Multicenter study of SpA-related uveitis refractory to at least one immunosuppressive drug. The main outcome variables were degree of anterior and posterior chamber inflammation, visual acuity, and macular thickness. Results: Fifteen patients (13 men/2 women; 18 affected eyes; mean age 39±6 years) were evaluated. The underlying SpA subtypes were ankylosing spondylitis (n=8), psoriatic arthritis (n=6) and non-radiographic axial SpA (n=1). The ocular involvement patterns were recurrent anterior uveitis in 8 patients and chronic anterior uveitis in 7. Before GLM they have received methotrexate (n=13), sulfasalazine (n=6), pulses of methylprednisolone (n=4), azathioprine (n=3), leflunomide (n=2) and cyclosporine (n=1). Ten of them had also been treated with TNF-? blockers; etanercept (n=7), adalimumab (n=7), infliximab (n=6), and certolizumab (n=1). GLM was given at the standard dose (50 mg/sc/monthly) as monotherapy (n=7) or in combination with conventional immunosuppressive drugs (n=8), mainly methotrexate. Most patients had rapid and progressive improvement of intraocular inflammation parameters. The median number of cells in the anterior chamber at 2 years (0 [0-0]) was significantly reduced compared to baseline findings (1 [0-3]); p=0.04). The mean best corrected visual acuity value also improved (0.84±0.3 at 2 years versus 0.62±0.3 at baseline; p=0.03). Only minor side effects were observed after a mean follow-up of 23±7 months. Conclusions: Our results indicate that GLM may be a useful therapeutic option in refractory SpA-related uveitis.

 Fuente: Seminars in Arthritis and Rheumatism Volume 46, Issue 1, August 2016, Pages 95-101

 Editorial: W.B. Saunders

 Fecha de publicación: 04/03/2016

 Nº de páginas: 27

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2016.03.002

 ISSN: 0049-0172,1532-866X

Autoría

CALVO RÍO, VANESA

SANTOS GÓMEZ, MONTSERRAT

RUBIO ROMERO, ESTEBAN

CORDERO COMA, MIGUEL

GALLEGO FLORES, ADELA

VEROZ, RAÚL

TORRE, IGNACIO

HERNÁNDEZ, FÉLIX FRANCISCO

ATANES, ANTONIO

JAVIER LORICERA GARCIA

MARIA CARMEN GONZALEZ VELA