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Abstract: Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
Fuente: Sci Rep. 2017 Feb 24;7:43263
Editorial: Nature Publishing Group
Fecha de publicación: 24/02/2017
Nº de páginas: 12
Tipo de publicación: Artículo de Revista
DOI: 10.1038/srep43263
ISSN: 2045-2322
Consultar en UCrea Leer publicación
IBÁÑEZ SANZ, GEMMA
DÍEZ VILLANUEVA, ANNA
ALONSO, M. HENAR
RODRÍGUEZ MORANTA, FRANCISCO
PÉREZ GÓMEZ, BEATRIZ
BUSTAMANTE, MARIONA
MARTIN, VICENTE
FRANCISCO JAVIER LLORCA DIAZ
AMIANO, PILAR
ARDANAZ, EVA
TARDÓN, ADONINA
JOSE JUAN JIMENEZ MOLEON
PEIRÓ, ROSANA
ALGUACIL, JUAN
NAVARRO, CARMEN
GUINÓ, ELISABET
BINEFA, GEMMA
FERNÁNDEZ NAVARRO, PABLO
ESPINOSA, ANNA
CAMILO PALAZUELOS CALDERON
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