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Abstract: Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1?22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1?22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.
Fuente: Front. Immunol. Nov 2016 7:541
Editorial: Frontiers Research Foundation
Fecha de publicación: 01/11/2016
Nº de páginas: 9
Tipo de publicación: Artículo de Revista
DOI: 10.3389/fimmu.2016.00541
ISSN: 1664-3224
Consultar en UCrea Leer publicación
RICARDO CALDERON GONZALEZ
HECTOR TERAN NAVARRO
MARIMON, JOSÉ MARÍA
GONZÁLEZ RICO, CLAUDIA
CALVO MONTES, JORGE
ELISABET FRANDE CABANES
ALKORTA GURRUTXAGA, MIRIAM
MARIA DEL CARMEN FARIÑAS ALVAREZ
LUIS MARTINEZ MARTINEZ
PÉREZ TRALLERO, EMILIO
CARMEN ALVAREZ DOMINGUEZ
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