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Specific premature epigenetic aging of cartilage in osteoarthritis

Abstract: Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone; and a blood-specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95 % CI = 1.1 to 6.3, P = 0.008) of OA patients. By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95 % CI = -1.8 to 1.9, P = 0.3) and in blood (-0.6 years; 95 % CI = -1.5 to 0.3, P = 0.2) between OA patients and controls. Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.

 Fuente: Aging (Albany NY). 2016 Sep 28;8(9):2222-2231

 Editorial: Impact Journals, LLC

 Año de publicación: 2016

 Nº de páginas: 10

 Tipo de publicación: Artículo de Revista

 DOI: 10.18632/aging.101053

 ISSN: 1945-4589

Autoría

VIDAL BRALO, L

LÓPEZ GOLÁN, Y

MERA VARELA, A

REGO PÉREZ, I

HORVATH, S

ZHANG, Y

ÁLVARO DEL REAL BOLT

ZHAI, G

GÓMEZ REINO, JJ

GONZÁLEZ, A