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The aim was to study the association between 25-hydroxyvitamin D (25(OH)D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD).
We studied a cross-section from the baseline visit of the CARMA project (CARdiovascular in rheuMAtology), a 10-year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain. Non-CIRD group was frequency matched by age with the joint distribution of the three CIRD groups included in the study. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were?20 ng/ml.
2.234 patients (775 RA, 738 AS and 721 PsA) and 677 non-CIRD subjects were assessed. The median (p25-p75) 25(OH)D levels were: 20.4 (14.4-29.2) ng/ml in RA, 20.9 (13.1-29.0) in AS, 20.0 (14.0-28.8) in PsA, and 24.8 (18.4-32.6) ng/ml in non-CIRD patients. We detected 25(OH)D deficiency in 40.5 % RA, 39.7 % AS, 40.9 % PsA and 26.7 % non-CIRD controls (p?0.001). A statistically significant positive association between RA and 25(OH)D deficiency was found (adjusted (adj.) OR?=?1.46; 95 % CI?=?1.09-1.96); p?=?0.012. This positive association did not reach statistical significance for AS (adj. OR 1.23; 95 % CI?=?0.85-1.80) and PsA (adj. OR 1.32; 95 % CI?=?0.94-1.84). When the parameters of disease activity, severity or functional impairment were assessed, a marginally significant association between 25(OH)D deficiency and ACPA positivity in RA patients (adj. OR?=?1.45; 95 % CI?=?0.99-2.12; p?=?0.056), and between 25(OH)D deficiency and BASFI in AS patients (adj. OR?=?1.08; 95 % CI?=?0.99-1.17); p?=?0.07) was also found.
Patients with RA show an increased risk of having 25(OH)D deficiency compared to non-CIRD controls.
Fuente: Arthritis Res Ther. 2015 Aug 14;17:211
Editorial: BioMed Central
Año de publicación: 2015
Nº de páginas: 10
Tipo de publicación: Artículo de Revista
URRUTICOECHEA ARANA, A
MARTÍN MARTÍNEZ, MA
GONZÁLEZ JUANATEY, CARLOS
FRANCISCO JAVIER LLORCA DIAZ
DÍAZ GONZÁLEZ, F
MIGUEL ANGEL GONZALEZ-GAY MANTECON