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 Detalle_Publicacion

Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis

Abstract: Introduction: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased cardiovascular (CV) disease risk. Interferon regulatory factor 5 (IRF5) is a regulator of type I interferon induction. Recently, researchers have described an association between multiple single-nucleotide polymorphisms of the IRF5 gene and some rheumatic disorders. In this study, we aimed to evaluate whether three different haplotype blocks within the IRF5 locus which have been shown to alter the protein function are involved in the risk of CV events occurring in Spanish RA patients. Methods: Three IRF5 polymorphisms (rs2004640, rs2070197 and rs10954213) representative of each haplotype group were genotyped by performing TaqMan assays using a 7900HT Fast Real-Time PCR System with tissue from a total of 2,137 Spanish patients diagnosed with RA. Among them, 390 (18.2%) had experienced CV events. The relationship of IRF5 genotypes and haplotypes to CV events was tested using Cox regression. Results: Male sex, age at RA diagnosis and most traditional risk factors (hypertension, dyslipidemia and smoking habit) were associated with increased risk for CV events in the RA population. Interestingly, a protective effect of both IRF5 rs2004640 GG and IRF5 rs10954213 GG genotypes against the risk for CV events after adjusting the results for sex, age at RA diagnosis and traditional CV disease risk factors was observed (hazard ratio (HR) = 0.6, 95% confidence interval (CI) = 0.38 to 0.92, P = 0.02; and HR = 0.58, 95% CI = 0.36 to 0.95, P = 0.03, respectively). Moreover, we detected a protective effect of the GTG haplotype against the risk for CV events after adjusting the results for potential confounding factors (HR = 0.72, 95% CI = 0.56 to 0.93, P = 0.012). Conclusions: Our results reveal that IRF5 gene variants are associated with risk of CV events in patients with RA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: García-Bermúdez M., López-Mejías R., Genre F., Castañeda S., Llorca J., González-Juanatey C., Corrales A., Ubilla B., Miranda-Filloy J.A., Pina T., Gómez-Vaquero C., Rodríguez-Rodríguez L., Fernández-Gutiérrez B., Balsa A., Pascual-Salcedo D., López-Longo F.J., Carreira P., Blanco R., Martín J., González-Gay M.A.,

 Fuente: Arthritis Research & Therapy, 2014, 16(4), 146

Editorial: BioMed Central

 Fecha de publicación: 10/07/2014

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/ar4608

ISSN: 1478-6354,1478-6362

 Proyecto español: RD12/0009 ; CD12/00425 ; RD12/0009/0013

Autoría

GARCÍA BERMÚDEZ, MERCEDES

LÓPEZ MEJÍAS, RAQUEL

GENRE, FERNANDA

CASTAÑEDA SANZ, SANTOS

FRANCISCO JAVIER LLORCA DIAZ

GONZÁLEZ JUANATEY, CARLOS

CORRALES MARTÍNEZ, ALFONSO

UBILLA GARCÍA, BEGOÑA

MIRANDA FILLOY, JOSÉ ALBERTO

PINA MURCIA, TRINITARIO

GÓMEZ VAQUERO, CARMEN

RODRÍGUEZ RODRÍGUEZ, LUIS

FERNÁNDEZ GUTIÉRREZ, BENJAMÍN

BALSA CRIADO, ALEJANDRO

PASCUAL SALCEDO, DORA

LÓPEZ LONGO, FRANCISCO J.

CARREIRA DELGADO, PATRICIA

MARTÍN IBÁÑEZ, JAVIER