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MicroRNA-30c-5p modulates neuropathic pain in rodents

Abstract: Neuropathic pain is a debilitating chronic syndrome that is often refractory to currently available analgesics. Aberrant expression of several microRNAs (miRNAs) in nociception-related neural structures is associated with neuropathic pain in rodent models. We have exploited the antiallodynic phenotype of mice lacking the bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a transforming growth factor-? (TGF-?) pseudoreceptor. We used these mice to identify new miRNAs that might be useful for diagnosing, treating, or predicting neuropathic pain. We show that, after sciatic nerve injury in rats, miR-30c-5p was up-regulated in the spinal cord, dorsal root ganglia, cerebrospinal fluid (CSF) and plasma and that the expression of miR-30c-5p positively correlated with the severity of allodynia. The administration of a miR-30c-5p inhibitor into the cisterna magna of the brain delayed neuropathic pain development and reversed fully established allodynia in rodents. The mechanism was mediated by TGF-? and involved the endogenous opioid system. In patients with neuropathic pain associated with leg ischemia, the expression of miR-30c-5p was increased in plasma and CSF compared to control patients without pain. Logistic regression analysis in our cohort of patients showed that the expression of miR-30c-5p in plasma and CSF, in combination with other clinical variables, might be useful to help to predict neuropathic pain occurrence in patients with chronic peripheral ischemia.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Tramullas M., Francés R., De La Fuente R., Velategui S., Carcelén M., García R., Llorca J., Hurlé M.A.,

 Fuente: Science Translational Medicine, 2018, 10(453), 6299

Editorial: American Association for the Advancement of Science

 Fecha de publicación: 01/08/2018

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.1126/scitranslmed.aao6299

ISSN: 1946-6234,1946-6242

Proyecto español: SAF2013-47434-R ; SAF2016-77732-R

Url de la publicación: https://dx.doi.org/10.1126/scitranslmed.aao6299

Autores/as

RAQUEL FRANCES ROMERO

VELATEGUI, SARA

MARIA CARCELEN LABRADOR

FRANCISCO JAVIER LLORCA DIAZ