Estamos realizando la búsqueda. Por favor, espere...
1585
37
173
25449
4190
2497
330
Abstract: INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.
Fuente: PLoS One. 2018 Aug 14;13(8):e0201750
Editorial: Public Library of Science
Año de publicación: 2018
Nº de páginas: 15
Tipo de publicación: Artículo de Revista
DOI: 10.1371/journal.pone.0201750
ISSN: 1932-6203
Url de la publicación: https://dx.doi.org/10.1371/journal.pone.0201750
Consultar en UCrea Leer publicación
INES GOMEZ ACEBO
TRINIDAD DIERSSEN SOTOS
CAMILO PALAZUELOS CALDERON
FERNÁNDEZ- NAVARRO, PABLO
CASTAÑO-VINYALS, GEMMA
JESSICA ALONSO MOLERO
URTIAGA, CARMEN
FERNÁNDEZ-VILLA, TANIA
ARDANAZ, EVA
RIVAS-DEL-FRESNO, MANUEL
MOLINA- BARCELÓ, ANA
JIMÉNEZ MOLEÓN, JOSÉ JUAN
GARCÍA MARTÍNEZ, LIDIA
AMIANO, PILAR
MARIA PAZ RODRIGUEZ CUNDIN
MORENO, VÍCTOR
PÉREZ GÓMEZ, BEATRIZ
ARAGONÉS, NURIA
KOGEVINAS, MANOLIS
POLLÁN, MARINA
FRANCISCO JAVIER LLORCA DIAZ
Volver