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Duration of active psychosis and functional outcomes in first-episode non-affective psychosis

Abstract: BACKGROUND: The duration of untreated psychosis (DUP) has been associated with negative outcomes in psychosis; however, few studies have focused on the duration of active psychotic symptoms after commencing treatment (DAT). In this study, we aimed to evaluate the effect of DUP and DAT on functional long-term outcomes (3 years) in patients with early psychosis. METHODS: We evaluated the Scale for the Assessment of Positive Symptoms (SAPS) at frequent intervals for 3 years after presentation to determine the DAT for 307 individuals with first-episode psychosis together with DUP and clinical variables. The functional outcomes were assessed using the Disability Assessment Scale (DAS) at three years, and functional recovery was defined as minimal impairment and return to activity. Associated variables, DAT and DUP were included in logistic regression models to predict functional outcomes. Receiver operating characteristic curves and Youden's index were applied to assess the best cut-off values. RESULTS: DAT, (Wald: 13.974; ExpB: 1.097; p?

 Fuente: European Psychiatry, 2018, 52, 29-37

 Editorial: Elsevier

 Año de publicación: 2018

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.eurpsy.2018.03.003

 ISSN: 0924-9338,1778-3585

 Url de la publicación: http://dx.doi.org/10.1016/j.eurpsy.2018.03.003

Authorship

JOSE MARIA PELAYO TERAN

GAJARDO GALÁN, VIRGINIA

MARCOS GOMEZ REVUELTA

VICTOR ORTIZ GARCIA DE LA FOZ

MARIA ROSA AYESA ARRIOLA

TABARÉS SEISDEDOS, RAFAEL

BENEDICTO CRESPO FACORRO