Buscar

Estamos realizando la búsqueda. Por favor, espere...

Towards a blood-based diagnostic panel for bipolar disorder

Abstract: Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Methods amd findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies. We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC)?0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel. Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD.

 Fuente: Brain, Behavior and Immunity, 2016, 52, 49-57

 Editorial: Elsevier

 Año de publicación: 2016

 Nº de páginas: 9

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.bbi.2015.10.001

 ISSN: 0889-1591,1090-2139

 Url de la publicación: https://www.doi.org/10.1016/j.bbi.2015.10.001

Autoría

HAENISCH, FRIEDER

COOPER, JASON D.

REIF, ANDREAS

KITTEL-SCHNEIDER, SARAH

STEINER, JOHANN

LEWEKE, F. MARKUS

ROTHERMUNDT, MATTHIAS

BEVEREN, NICO J.M. VAN

BENEDICTO CRESPO FACORRO

NIEBUHR, DAVID W.

COWAN, DAVID N.

WEBER, NATALYA S.

YOLKEN, ROBERT H.

PENNINX, BRENDA W.J.H.

BAHN, SABINE