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Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Abstract: Introduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas covered: This review summarizes the main epidemiologic, pathophysiological, and clinical risk factors of CV disease associated with IJDs. Less common aspects on early diagnosis and risk stratification of the CV disease in these conditions are also discussed. In Europe, the most commonly used risk algorithm in patients with IJDs is the modified SCORE index based on the revised recommendations proposed by the EULAR task force in 2017.Expert opinion: Early identification of IJD patients at high risk of CV disease is essential. It should include the use of complementary noninvasive imaging techniques. A multidisciplinary approach aimed to improve heart-healthy habits, including strict control of classic CV risk factors is crucial. Adequate management of the underlying IJD is also of main importance since the reduction of disease activity decreases the risk of CV events. Non-steroidal anti-inflammatory drugs may have a lesser harmful effect in IJD than in the general population, due to their anti-inflammatory effects along with other potential beneficial effects.

 Fuente: J Clin Med. 2019 Nov 18;8(11). pii: E2013

 Editorial: MDPI AG

 Año de publicación: 2019

 Nº de páginas: 13

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm8112013

 ISSN: 2077-0383

 Url de la publicación: https://www.doi.org/10.3390/jcm8112013

Autoría

CAVAGNA, LORENZO

TRALLERO-ARAGUÁS, ERNESTO

MELONI, FEDERICA

CAVAZZANA, ILARIA

ROJAS-SERRANO, JORGE

FEIST, EUGEN

ZANFRAMUNDO, GIOVANNI

MORANDI, VALENTINA

MEYER, ALAIN

PEREIRA DA SILVA, JOSE ANTONIO

MATOS COSTA, CARLO JORGE

MOLBERG, OYVIND

ANDERSSON, HELENA

CODULLO, VERONICA

MOSCA, MARTA

BARSOTTI, SIMONE