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Cell death in the developing vertebrate limb: a locally regulated mechanism contributing to musculoskeletal tissue morphogenesis and differentiation

Abstract: Our aim is to critically review current knowledge of the function and regulation of cell death in the developing limb. We provide a detailed, but short, overview of the areas of cell death observed in the developing limb, establishing their function in morphogenesis and structural development of limb tissues. We will examine the functions of this process in the formation and growth of the limb primordia, formation of cartilaginous skeleton, formation of synovial joints, and establishment of muscle bellies, tendons, and entheses. We will analyze the plasticity of the cell death program by focusing on the developmental potential of progenitors prior to death. Considering the prolonged plasticity of progenitors to escape from the death process, we will discuss a new biological perspective that explains cell death: this process, rather than secondary to a specific genetic program, is a consequence of the tissue building strategy employed by the embryo based on the formation of scaffolds that disintegrate once their associated neighboring structures differentiate.

 Autoría: Montero J.A., Lorda-Diez C.I., Sanchez-Fernandez C., Hurle J.M.,

 Fuente: Developmental Dynamics, 2021, 250(9), 1236-1247

 Editorial: Wiley-Liss

 Año de publicación: 2021

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: 10.1002/dvdy.237

 ISSN: 1058-8388,1097-0177

 Proyecto español: BFU2017-84046-P

 Url de la publicación: https://doi.org/10.1002/dvdy.237