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Plant-derivatives small molecules with antibacterial activity

Abstract: The vegetal world constitutes the main factory of chemical products, in particular secondary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacological properties, and validation in clinical trials. This review presents an update of the main contributions published on the subject, focusing on the compounds that showed activity against multidrug-resistant relevant bacterial human pathogens, paying attention to their mechanisms of action and synergism with classical antibiotics.

 Fuente: Antibiotics (Basel, Switzerland), 2021, 10(3), 231

Editorial: MDPI

 Año de publicación: 2021

Nº de páginas: 19

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/antibiotics10030231

ISSN: 2079-6382

Url de la publicación: https://doi.org/10.3390/antibiotics10030231