Abstract: We aimed to study the association between occupational exposure to pesticides and
chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides,
four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish
population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain,
2010?2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs
the product of prevalence, intensity and duration of exposure to each active substance. Principal
components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and
occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed
to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of
CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend;
2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA,
the first component (PC1, explaining 70% of the variation) equally led by seven active substances
(the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of
having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm
previous associations between CLL and exposure to pesticides and provide additional evidence
by application groups and active substance. However, more research is needed to disentangle
independent eects of individual active substances.
Fuente: Int. J. Environ. Res. Public Health 2020, 17(14), 5174
Editorial: MDPI
Fecha de publicación: 17/07/2020
Nº de páginas: 11
Tipo de publicación: Artículo de Revista
DOI: 10.3390/ijerph17145174
ISSN: 1661-7827,1660-4601
Proyecto español: PMP15/00007
Url de la publicación: https://doi.org/10.3390/ijerph17145174