Search

Searching. Please wait…

Association of combined anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies with increased Sjögren disease severity through interferon pathway activation

Abstract: Objective: The biologic diagnosis of primary Sjögren disease (SjD) mainly relies on anti-Ro60/SSA antibodies, whereas the significance of anti-Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti-Ro52/TRIM21 antibody status. Methods: Patients with SjD from the European PRECISESADS (n = 376) and the Brittany Diagnostic Suspicion of primitive Sjögren's Syndrome (DIApSS); (n = 146) cohorts were divided into four groups: double negative (Ro52?/Ro60?), isolated anti-Ro52/TRIM21 positive (Ro52+), isolated anti-Ro60/SSA positive (Ro60+), and double-positive (Ro52+/Ro60+) patients. Clinical information; EULAR Sjögren Syndrome Disease Activity Index, a score representing systemic activity; and biologic markers associated with disease severity were evaluated. Transcriptome data obtained from whole blood by RNA sequencing and type I and II interferon signatures were analyzed for PRECISESADS patients. Results: In the DIApSS cohort, Ro52+/Ro60+ patients showed significantly more parotidomegaly (33.3% vs 0%?11%) along with higher ?2-microglobulin (P =?0.0002), total immunoglobulin (P

 Fuente: Arthritis and Rheumatology, 2024, 76(5), 751-762

 Publisher: John Wiley and Sons Ltd

 Year of publication: 2024

 No. of pages: 12

 Publication type: Article

 DOI: 10.1002/art.42789

 ISSN: 2326-5205,2326-5191

 Publication Url: https://doi.org/10.1002/art.42789

Authorship

BETTACCHIOLI, ELÉONORE

SARAUX, ALAIN

TICSON, ALICE

CORNEC, DIVI

DUEYMES, MARYVONNE

FOULQUIER, NATHAN

HILLION, SOPHIE

ROGUEDAS-CONTIOS, ANNE-MARIE

BENYOUSSEF, ANAS-ALEXIS

ALARCON-RIQUELME, MARTA E.

PERS, JACQUES-OLIVIER

DEVAUCHELLE-PENSEC, VALÉRIE

ALFONSO FERNANDO CORRALES MARTINEZ