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Uveitis in psoriatic arthritis: study of 406 patients in a single university center and literature review

Abstract: Background/purpose: The manifestations of uveitis are well established in axial spondyloarthritis (ax-SpA), but not in psoriatic arthritis (PsA). We aimed to assess, in a large unselected series of PsA: (A) the frequency and clinical features of uveitis; (B) its association with PsA activity, the impact of disease and functional disability, and (C) its relationship with the biological treatment. In addition, a literature review was performed. Methods: Retrospective longitudinal study of PsA patients from a single referral hospital. PsA was classified according to the CASPAR criteria, and uveitis was diagnosed by experienced ophthalmologists. Results: We studied 406 patients with PsA (46.3±12.3 years). Uveitis was observed in 20 (4.9%). Uveitis was acute in all cases, anterior (80%), unilateral (80%) and recurrent (50%). Patients with uveitis had a higher prevalence of HLA-B27 (45% vs 7.5%, p<0.0001), sacroiliitis on MRI (25% vs 8.3% p=0.027), ocular surface pathology (10% vs 0.8%, p=0.021), and median PsA impact of Disease Score (5.9 (2.1-6.8) vs 1.25 (0.0-3.0), p=0.001) and Bath Ankylosing Spondylitis Functional Index (4 (1.6-5) vs 1.0 (0.0-3.5), p=0.01) than patients without uveitis.The exposure adjusted incidence rate (episodes/100 patients-year) of uveitis before versus after biological treatment decreased with anti-TNF? monoclonal antibodies (56.3 vs 9.4) and increased with etanercept (ETN) (6.03 vs 24.2) and secukinumab (SECU) (0 vs 50) (including only one patient treated in the last two cases). Conclusion: The prevalence of uveitis in patients with PsA was about 5%. The pattern was similar to that observed in ax-SpA. Uveitis was associated with a worse quality of life and greater functional disability. The uveitis exposure adjusted incidence rate decreased with anti-TNF? monoclonal antibodies and increased with ETN and SECU.

 Autoría: De Vicente Delmás A., Sanchez-Bilbao L., Calvo-Río V., Martínez-López D., Herrero-Morant A., Galíndez-Agirregoikoa E., Gonzalez-Mazon I., Barroso-García N., Palmou-Fontana N., Gonzalez-Gay M.A., Hernández J.L., Blanco R.,

 Fuente: RMD Open, 2023, 9, e002781

 Editorial: BMJ Publishing Group

 Año de publicación: 2023

 Nº de páginas: 8

 Tipo de publicación: Artículo de Revista

 DOI: 10.1136/rmdopen-2022-002781

 ISSN: 2056-5933

Autoría

VICENTE DELMÁS, ANA DE

LARA SANCHEZ BILBAO

VANESA CALVO DEL RIO

MARTÍNEZ-LÓPEZ, DAVID

HERRERO-MORANT, ALBA

GALÍNDEZ-AGIRREGOIKOA, EVA

IÑIGO GONZALEZ MAZON

BARROSO-GARCÍA, NURIA

NATALIA PALMOU FONTANA