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Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study

Abstract: Background: Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms. Objective: This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain. Methods: The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp). Results: Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR=2.08; 95% CI=1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR=2.08; 95% CI=1.13?3.88, OR=4.40; 95% CI=1.65-13.33, and OR?=?5.25; 95% CI?=?1.84?17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR?=?4.16; 95% CI?=?1.59?12.32), while the cleaning exposure scenario was not (OR?=?1.22; 95% CI?=?0.55?2.67). Conclusions: Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour

 Autoría: Peñalver-Piñol A., Benavente Y., Frias-Gomez J., Alguacil J., Santibañez M., Contreras-Llanes M., Peremiquel-Trillas P., López-Querol M., Paytubi S., Pelegrina B., Onieva I., Martínez J.M., Fernandez-Gonzalez S., Francisco J.d., Caño V., Brunet J., Pineda M., Ponce J., Matias-Guiu X., Bosch F.X., Sanjosé S.d., Alemany L., Costas L.,

 Fuente: Environmental Health: A Global Access Science Source, 2023, 22, 77

 Editorial: Springer

 Año de publicación: 2023

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1186/s12940-023-01028-0

 ISSN: 1476-069X

Autoría

PEÑALVER PIÑOL, ARNAU

BENAVENTE, YOLANDA

FRÍAS GÓMEZ, JON

ALGUACIL, JUAN

CONTRERAS LLANES, MANUEL

PEREMIQUEL TRILLAS, PAULA

LÓPEZ QUEROL, MARTA

PAYTUBI, SONIA

PELEGRINA, BEATRIZ

ONIEVA, IRENE

MARTÍNEZ, JOSÉ MANUEL

FERNÁNDEZ-GONZALEZ, SERGI

DE FRANCISCO, JAVIER

CAÑO, VICTOR

BRUNET, JOAN

PINEDA, MARTA

PONCE, JORDI

MARIAS GUIU, XAVIER

BOSCH, FRANCESC XAVIER

DE SANJOSE, SILVIA

ALEMANY, LAIA

COSTAS, LAURA