Abstract: Background. The cytokine interleukin-6 (IL-6) is important in both immune responses and cardiovascular diseases. The IL-6 promoter polymorphism 174 G/C is associated with increased plasma concentrations of IL-6. The relationship between IL-6 polymorphisms and graft survival, cardiovascular events, and new-onset diabetes mellitus after kidney transplantation is controversial. Objective. To analyze whether IL-6 ( 174 G/C) polymorphism influences kidney graft survival or development of chronic allograft nephropathy, cardiovascular events, or newonset diabetes. Methods. The IL-6 promoter polymorphism ( 174 G/C) was analyzed using the polymerase chain reaction with sequence-specific primers in 335 kidney transplant recipients. Data for graft survival, chronic graft nephropathy, cardiovascular events, and new-onset diabetes were obtained retrospectively from clinical records. Categorical variables were compared between individuals with CC, GG, and GC genotypes using 2 tests. Survival analysis was performed using the Kaplan-Meier method, comparing groups using the log-rank test. . No significant differences were observed in 5-year graft survival between individuals with CC and GC/GG genotypes (85.3% vs 77.1%; P .22). Nor were significant differences noted in the rates of chronic allograft nephropathy (37.5% vs 33.8%; P .48), cardiovascular events (10.0% vs 23.0%; P .10), or new-onset diabetes (7.5% vs 11.8%; P .28). Conclusion. There is no association between IL-6 ( 174 G/C) polymorphism and graft survival or development of chronic allograft nephropathy, cardiovascular events, or newonset diabetes.

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