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Abstract: Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
Fuente: Nutrients. 2019 Jun 21;11(6). pii: E1406
Editorial: MDPI
Año de publicación: 2019
Nº de páginas: 20
Tipo de publicación: Artículo de Revista
DOI: 10.3390/nu11061406
ISSN: 2072-6643
Url de la publicación: https://www.doi.org/10.3390/nu11061406
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OBÓN-SANTACANA, MIREIA
ROMAGUERA, DORA
GRACIA-LAVEDAN, ESTHER
MOLINUEVO, AMAIA
MOLINA-MONTES, ESTHER
SHIVAPPA, NITIN
HEBERT, JAMES R.
TARDÓN, ADONINA
CASTAÑO-VINYALS, GEMMA
MORATALLA, FERRAN
GUINÓ, ELISABET
MARCOS-GRAGERA, RAFAEL
AZPIRI, MIKEL
GIL, LEIRE
OLMEDO-REQUENA, ROCÍO
LOZANO-LORCA, MACARENA
ALGUACIL, JUAN
FERNÁNDEZ-VILLA, TANIA
TRINIDAD DIERSSEN SOTOS
INES GOMEZ ACEBO
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