Inicio de sesión

Contact​​

Dra. Federica Bertocchini


Phone: (+34) 942 206851 / Fax : (+34) 942 266399
Email: bertocchinif@unican.es
Mailing address: IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander​​

Early development of the amniote embryo

Federica.jpg


​Principal Investigator​

Federica Bertocchini, Ramón y Cajal researcher

 

Other personnel​​​

  • Lucía Carrera Fernández, predoctoral
  • Cristina Aceituno Caballero, technician


​Web site

 http://federicabertocchini.com/


 Research interests

  • Axis formation 
  • Primordial Germ Cells specification and maintenance in the early embryo
  • Early endoderm formation and patterning
  • Chick Embryonic Stem Cells (cESC)

Funding​

  • Ministry of Science and Innovation, Government of Spain, National Plan I+D+I for not oriented research. Grant number: BFU2010-19656 (2010)
  • Fundacion Ramon Areces, XIV Concurso Ciencias de la Vida y de la Materia (2012)
  • Royal Society International exchange grant with Dr. S. Srinivas, Oxford University, Oxford, UK (07/2013-06/2014)

Publications​​

  • Germline development in amniotes: A paradigm shift in primordial germ cell specification. Bertocchini F, Chuva de Sousa Lopes SM.
    Bioessays
    . 2016 Aug;38(8):791-800. doi: 10.1002/bies.201600025. Epub 2016 Jun 6. [PubMed]

  • The Veiled Chameleon (Chamaeleo calyptratus Duméril and Duméril 1851): A Model for Studying Reptile Body Plan Development and Evolution. Diaz RE Jr, Anderson CV, Baumann DP, Kupronis R, Jewell D, Piraquive C, Kupronis J, Winter K, Bertocchini F, Trainor PA.
    Cold Spring Harb Protoc
    . 2015 Aug 26;2015(10):889-94. doi: 10.1101/pdb.emo087700. [PubMed]

  • Bi-modal strategy of gastrulation in reptiles. Stower MJ, Diaz RE, Fernandez LC, Crother MW, Crother B, Marco A, Trainor PA, Srinivas S, Bertocchini F.
    Dev Dyn
    . 2015 Jun 19. doi: 10.1002/dvdy.24300. [PubMed]

  • Transcriptome analysis of chicken ES, blastodermal and germ cells reveals that chick ES cells are equivalent to mouse ES cells rather than EpiSC. Jean C, Oliveira NM, Intarapat S, Fuet A, Mazoyer C, De Almeida I, Trevers K, Boast S, Aubel P, Bertocchini F, Stern CD, Pain B.

    Stem Cell Res. 2015 Jan;14(1):54-67. doi: 10.1016/j.scr.2014.11.005. Epub 2014 Dec 5. [PubMed]

  • HINTW, a W-chromosome HINT gene in chick, is expressed ubiquitously and is a robust female cell marker applicable in intraspecific chimera studies. Nagai H, Sezaki M, Bertocchini F, Fukuda K, Sheng G.
    Genesis
    . 2014 May;52(5):424-30. doi: 10.1002/dvg.22769. [PubMed]

  • Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula. Compagnucci C, Debiais-Thibaud M, Coolen M, Fish J, Griffin JN, Bertocchini F, Minoux M, Rijli FM, Borday-Birraux V, Casane D, Mazan S, Depew MJ.
    Dev Biol
    . 2013 May 15;377(2):428-48. doi: 10.1016/j.ydbio.2013.02.022. [PubMed]

  • A little winning streak: the reptilian-eye view of gastrulation in birds. Bertocchini F, Alev C, Nakaya Y, Sheng G.
    Dev Growth Differ
    . 2013 Jan;55(1):52-9. doi: 10.1111/dgd.12014. [PubMed]

  • Gata2 provides an early anterior bias and uncovers a global positioning system for polarity in the amniote embryo. Bertocchini F, Stern CD.
    Development
    . 2012 Nov;139(22):4232-8. doi: 10.1242/dev.081901. [PubMed]
  • A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations. Garrido-Allepuz C, Haro E, González-Lamuño D, Martínez-Frías ML, Bertocchini F, Ros MA.
    Dis Model Mech
    . 2011 May;4(3):289-99. doi: 10.1242/dmm.007732. [PubMed]
  • A differential screen for genes expressed in the extraembryonic endodermal layer of pre-primitive streak stage chick embryos reveals expression of Apolipoprotein A1 in hypoblast, endoblast and endoderm. Bertocchini F, Stern CD.
    Gene Expr Patterns
    . 2008 Sep;8(7-8):477-80. doi: 10.1016/j.gep.2008.07.001. [PubMed]
  • The amniote primitive streak is defined by epithelial cell intercalation before gastrulation. Voiculescu O, Bertocchini F, Wolpert L, Keller RE, Stern CD.
    Nature
    . 2007 Oct 25;449(7165):1049-52. [PubMed]
  • The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells. Lavial F, Acloque H, Bertocchini F, Macleod DJ, Boast S, Bachelard E, Montillet G, Thenot S, Sang HM, Stern CD, Samarut J, Pain B.
    Development
    . 2007 Oct;134(19):3549-63. [PubMed]
  • Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo. Bertocchini F, Skromne I, Wolpert L, Stern CD.
    Development
    . 2004 Jul;131(14):3381-90. [PubMed]
  • The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling. Bertocchini F, Stern CD.
    Dev Cell
    . 2002 Nov;3(5):735-44. [PubMed]
  • Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. Balschun D, Wolfer DP, Bertocchini F, Barone V, Conti A, Zuschratter W, Missiaen L, Lipp HP, Frey JU, Sorrentino V.
    EMBO J
    . 1999 Oct 1;18(19):5264-73. [PubMed]
  • Voltage-controlled Ca2+ release in normal and ryanodine receptor type 3 (RyR3)-deficient mouse myotubes. Dietze B, Bertocchini F, Barone V, Struk A, Sorrentino V, Melzer W.
    J Physiol
    . 1998 Nov 15;513 ( Pt 1):3-9. [PubMed]
  • Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel. Sonnleitner A, Conti A, Bertocchini F, Schindler H, Sorrentino V.
    EMBO J
    . 1998 May 15;17(10):2790-8. [PubMed]
  • Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors. Barone V, Bertocchini F, Bottinelli R, Protasi F, Allen PD, Franzini Armstrong C, Reggiani C, Sorrentino V.
    FEBS Lett
    . 1998 Jan 30;422(2):160-4. [PubMed]
  • Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. Bertocchini F, Ovitt CE, Conti A, Barone V, Schöler HR, Bottinelli R, Reggiani C, Sorrentino V.
    EMBO J
    . 1997 Dec 1;16(23):6956-63. [PubMed]