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Abstract: Melphalan flufenamide (melflufen) is a first-in-class peptide?drug conjugate that takes advantage of increased aminopeptidase activity inside tumor cells to rapidly release alkylating agents therein. Melflufen in combination with dexamethasone has been evaluated in multiple clinical trials in patients with relapsed/refractory multiple myeloma (MM).
Fuente: Expert Rev Clin Pharmacol . 2022 Apr;15(4):371-382
Publisher: Taylor & Francis
Year of publication: 2022
No. of pages: 12
Publication type: Article
DOI: 10.1080/17512433.2022.2075847
ISSN: 1751-2433,1751-2441
Publication Url: https://doi.org/10.1080/17512433.2022.2075847
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ENRIQUE MARIA OCIO SAN MIGUEL
NADEEM, OMAR
SCHJESVOLD, FREDRIK
GAY, FRANCESCA
TOUZEAU, CYRILLE
DIMOPOULOS, MELETIOS A.
RICHARDSON, PAUL G.
MATEOS, MARIA-VICTORIA
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