Abstract: The increased sympathetic nervous activity causes bone loss, via an increase in osteoclastic bone resorption and a decrease in osteoblastic bone formation, suggesting an important regulating role for the SNS in bone metabolism. Such findings may indicate that pharmacological beta-blockade could be a target to increase bone mass and reduce the risk of fractures. This review summarized the impact of beta-blockers on bone mineral density, bone turnover markers and fracture risk.

Authorship

Download reference