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B-cell overexpression of Bcl-2 cooperates with p21 deficiency for the induction of autoimmunity and lymphomas

Abstract: Genetic abnormalities predisposing to autoimmunity generally act in a cooperative manner affecting one or several mechanisms regulating immunological tolerance. In addition, many of these genetic abnormalities are also involved in the development of lymphoproliferative diseases. In the present study, we have determined the possible cooperation between deficiencies in members of the Cip/Kip family of cell cycle regulators (p21WAF1/Cip1 or p27kip1) and the overexpression of human Bcl-2 in B lymphocytes in the induction of autoimmune and lymphoproliferative diseases in non-autoimmune C57BL/6 (B6) mice. Unlike single mutant mice, B6.p21?/? mice transgenic for human Bcl-2 in B cells developed a lethal autoimmune syndrome characterized by the production of autoantibodies, the prominent expansion of memory B and CD4+ T cells and the development of severe glomerular lesions resembling IgA nephropathy. Furthermore, these mice presented a high incidence of B-cell lymphoproliferative disorders. Such genetic cooperation in the induction of autoimmunity was not observed in B6.p27?/? mice transgenic for human Bcl-2 in B cells. Altogether, what we have demonstrated here is the existence of preferential interactions among particular regulators of the G1/S transition of the cell cycle and B-cell survival in the induction of systemic autoimmune and lymphoproliferative diseases.

 Authorship: Santiuste I., Buelta L., Iglesias M., Genre F., Mazorra F., Izui S., Merino J., Merino R.,

 Fuente: Journal of Autoimmunity, 2010, 35(4), 316-324

 Publisher: Elsevier

 Year of publication: 2010

 No. of pages: 9

 Publication type: Article

 DOI: 10.1016/j.jaut.2010.07.002

 ISSN: 1095-9157,0896-8411

Authorship

INES SANTIUSTE TORCIDA

BUELTA, LUIS

MARCOS IGLESIAS LOZANO

FERNANDA GENRE

MAZORRA, FRANCISCO

IZUI, SHOZO