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Abstract: Anti-CD19 chimeric antigen receptor T cells (CART) has rapidly been adopted as the standard third-line therapy to treat aggressive B-cell lymphomas (ABCL) after failure of second-line therapy despite the lack of direct comparisons with allogeneic hematopoietic cell transplantation (alloHCT)-based strategies. Using the Grupo Español de Trasplante y Terapia Celular (GETH-TC) registry, we selected patients with the following characteristics: CART or alloHCT performed between 2016 and 2021; >18 years old; ABCL diagnosis; 2 lines of therapy; and either anti-CD19 CART or alloHCT as therapy at relapse. The analysis included a total of 316 (CART=215, alloHCT=101) patients. Median follow-up was 15 and 36 months for the CART and alloHCT cohorts, respectively. In the multivariate analysis, CART was confirmed to be similar to alloHCT for the primary study endpoint (progression-free survival) (hazard ratio [HR] 0.92, CI95%:0.56-1.51, p=0.75). Furthermore, when the analysis was limited to only patients with chemo-sensitive diseases (complete and partial response) at infusion (CART=26, alloHCT=93), no differences were reported (progression-free survival at month +18: 65% versus 55%, p =0.59). However, CART had lower non-relapse mortality (HR 0.34, 95% CI: 0.13-0.85, p=0.02). Given the lower toxicity and similar survival outcomes, these results suggest the use of CART before alloHCT
Fuente: Bone Marrow Transplantation, 2023, 58(6), 673-679 - (CORRIGENTUM), 2023, 58(6), 673-679
Publisher: Nature Publishing Group
Year of publication: 2023
No. of pages: 7
Publication type: Article
DOI: 10.1038/s41409-023-01949-x
ISSN: 0268-3369,1476-5365
Publication Url: https://doi.org/ 10.1038/s41409-023-01949-x
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MUSSETTI, ALBERTO
BENTO, LEYRE
BASTOS-OREIRO, MARIANA
RIUS-SANSALVADOR, BLANCA
ALBO, CARMEN
BAILEN, REBECA
BARBA, PERE
BENZAQUÉN, ANA
BRIONES, JAVIER
CAROLINA CABALLERO, ANA
CAMPOS, ANTÓNIO
ESPAÑOL, IGNACIO
FERRA, CHRISTELLE
GARZÓN LÓPEZ, SEBASTIÁN
GONZÁLEZ SIERRA, PEDRO ANTONIO
GUERRA, LUISA MARIA
HERNANI, RAFAEL
IACOBONI, GLORIA
LUCRECIA YAÑEZ SAN SEGUNDO
JIMÉNEZ-UBIETO, ANA
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