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Abstract: OBJECTIVE: Cutaneous vasculitis (CV) encompasses a wide group of entities characterized by inflammation of skin blood vessels. The term single-organ vasculitis was recently coined by the 2012 Chapel Hill Consensus Conference (CHCC) to define vasculitis affecting a single organ. To our knowledge there are no published reports on single-organ cutaneous small vessel vasculitis (SoCSVV). Our aim was to characterize this entity from a wide series of patients with CV. METHODS: We analysed cases of SoCSVV from a series of 766 patients with CV from a single university referral centre. According to 2012 CHCC, the following conditions were required to define SoCSVV: (i) skin biopsy showing characteristic leucocytoclastic vasculitis and (ii) vasculitis limited to skin. RESULTS: We included 60 patients (26 women and 34 men) with a mean age of 56 years. The main precipitating factors for SoCSVV were drugs [26 patients (52%)] and previous infection [17 patients (34%)]. The main clinical manifestations were palpable purpura (81.7%) and fever (18.3%). The most frequent laboratory findings were leucocytosis and elevated ESR. Nearly one-quarter of patients with SoCSVV required pharmacological therapy. Corticosteroids (15%) and NSAIDs (13.3%) were the main agents prescribed. After a median follow-up of 4 months, complete recovery was observed in all the patients, although relapses occurred in 8% of patients. CONCLUSION: SoCSVV defined according to the 2012 CHCC may be considered a benign disease usually associated with drugs and/or a previous infection.
Fuente: Rheumatology, 2015, 54(1), 77-82
Publisher: Oxford University Press
Year of publication: 2015
No. of pages: 6
Publication type: Article
DOI: 10.1093/rheumatology/keu295
ISSN: 1462-0324,1462-0332
Spanish project: RD08/0075 ; RD12/0009/0013
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LORICERA, JAVIER
RICARDO BLANCO ALONSO
ORTIZ SANJUÁN, FRANCISCO
JOSE LUIS HERNANDEZ HERNANDEZ
PINA MURCIA, TRINITARIO
MARIA CARMEN GONZALEZ VELA
CALVO RÍO, VANESA
JAVIER RUEDA GOTOR
JESUS LINO ALVAREZ GRANDA
MARCOS ANTONIO GONZALEZ LOPEZ
MARCELLÁN, MARÍA
MIGUEL ANGEL GONZALEZ-GAY MANTECON
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