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Abstract: Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
Fuente: International Journal of Molecular Sciences, 2023, 24, 14250
Publisher: MDPI
Year of publication: 2023
No. of pages: 14
Publication type: Article
DOI: 10.3390/ijms241814250
ISSN: 1661-6596,1422-0067
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CALLEJÓN-LECLIC, BELÉN
SÁNCHEZ ESPIRILLA, SAIDA
GOTERA-RIVERA, CAROLINA
SANTANA, RAFAEL
DÍAZ-OLIVARES, ISABEL
MARÍN, JOSÉ M.
CASANOVA MACARIO, CIRO
GARCÍA COSÍO, BORJA
FUSTER, ANTONIA
SOLANES GARCÍA, INGRID
TORRES, JUAN P. DE
FEU COLLADO, NURIA
CABRERA LÓPEZ, CARLOS
CARLOS ANTONIO AMADO DIAGO
ROMERO PLAZA, AMPARO
PADRÓN FRAYSSE, LUIS ALEJANDRO
MÁRQUEZ MARTÍN, EDUARDO
MARÍN ROYO, MARGARITA
BALCELLS VILARNAU, EVA
LLUNELL CASANOVAS, ANTONIA
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