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Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

Abstract: Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ?30 years (AOR=1.75; 95% CI: 1.04?2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ?10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11?0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47?0.98) or 10?25 pack-years (AOR=0.62; 95% CI: 0.42?0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.

 Fuente: Tobacco Induced Diseases, 2023, 21(November), 4

 Publisher: BioMed Central

 Year of publication: 2023

 No. of pages: 16

 Publication type: Article

 DOI: 10.18332/tid/174132

 ISSN: 1617-9625

 Publication Url: https://doi.org/10.18332/tid/174132

Authorship

PEÑALVER-ARGÜESO, BELÉN

GARCÍA-ESQUINAS, ESTHER

CASTELLÓ, ADELA

FERNÁNDEZ DE LARREA-BAZ, NEREA

CASTAÑO-VINYALS, GEMMA

AMIANO, PILAR

FERNÁNDEZ-VILLA, TANIA

GUEVARA, MARCELA

FERNÁNDEZ-TARDÓN, GUILLERMO

ALGUACIL, JUAN

OBÓN-SANTACANA, MIREIA

PINTO-CARBÓ, MARINA

MARCOS-GRAGERA, RAFAEL

ARAGONÉS, NURIA

AIZPURUA, AMAIA

MARTÍN-SÁNCHEZ, VICENTE

ARDANAZ, EVA

JIMÉNEZ-MOLEÓN, JOSÉ JUAN