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Abstract: Most bacteria in nature exist as biofilms, which support intercellular signalling processes such as quorum sensing (QS), a cell-to-cell communication mechanism that allows bacteria to monitor and respond to cell density and changes in the environment. As QS and biofilms are involved in the ability of bacteria to cause disease, there is a need for the development of methods for the non-invasive analysis of QS in natural bacterial populations. Here, by using surface-enhanced resonance Raman scattering spectroscopy, we report rationally designed nanostructured plasmonic substrates for the in situ, label-free detection of a QS signalling metabolite in growing Pseudomonas aeruginosa biofilms and microcolonies. The in situ, non-invasive plasmonic imaging of QS in biofilms provides a powerful analytical approach for studying intercellular communication on the basis of secreted molecules as signals.
Fuente: Nature Materials, 2016, 15, 1203-1211
Publisher: Nature Publishing Group
Year of publication: 2016
No. of pages: 9
Publication type: Article
DOI: 10.1038/nmat4720
ISSN: 1476-1122,1476-4660
Publication Url: http://dx.doi.org/10.1038/nmat4720
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BODELÓN, GUSTAVO
MONTES-GARCÍA, VERÓNICA
LÓPEZ-PUENTE, VANESA
HILL, ERIC H.
HAMON, CYRILLE
MARTA NORAH SANZ ORTIZ
RODAL-CEDEIRA, SERGIO
COSTAS, CELINA
CELIKSOY, SIRIN
PÉREZ-JUSTE, IGNACIO
SCARABELLI, LEONARDO
LA PORTA, ANDREA
PÉREZ-JUSTE, JORGE
PASTORIZA-SANTOS, ISABEL
LIZ-MARZÁN, LUIS M.
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