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Abstract: Aims Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders. Methods and results Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations. Conclusions Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.
Fuente: Histopathology Volume 65, Issue 6, 2014 Pages 805–813
Publisher: Wiley
Publication date: 30/10/2014
No. of pages: 9
Publication type: Article
DOI: 10.1111/his.12511
ISSN: 1365-2559,0309-0167
Publication Url: http://onlinelibrary.wiley.com/doi/10.1111/his.12511/full
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MARTÍNEZ-LÓPEZ, AZAHARA
SANTIAGO MONTES MORENO
RAMOS, RAFAEL
AFONSO-MARTÍN, JUAN LUIS
FRANCISCO JOSE MAZORRA MACHO
SONIA GONZALEZ DE VILLAMBROSIA
MARIA ANA BATLLE LOPEZ
GROGAN, THOMAS M.
MIGUEL ANGEL PIRIS PINILLA
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