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Abstract: Objective. To determine if cutaneous vasculitis (CV) associated with severe infection has some histopathologic findings that may help us to differentiate patients with this condition from other patients with CV. Methods. We reviewed the skin biopsy specimens of patients with leukocytoclastic CV associated with a severe bacterial infection. Histopathologic findings of these patients were compared with those observed in leukocytoclastic CV secondary to other causes. Biopsy-proven leukocytoclastic CV were stratified as follows: group a): CV associated with severe underlying bacterial infection; group b): CV without severe bacterial infection but with systemic involvement; group c): CV without systemic involvement. Slides were reviewed by expert pathologists that were blind to the clinical information. The severity of vascular lesions was measured according to a semiquantitative scale (Hodge index). A comparative study between group a) and the other groups was conducted. Results. group a) included 12 patients (2 women/10 men), mean age± SD 56±15 years; group b) 21 patients (10 women/11 men), 52±18 years; and group c) 19 patients (12 women/7 men), 59±24 years. Presence of neutrophilia was significantly increased in biopsies from group a) when compared with the other two groups. Also, a trend to higher frequency of pustular dermatosis was found in patients from group a). Hodge index, degree of inflammatory infiltrate and deep arterioles involvement were similar in all groups. Conclusion. Neutrophilia is common in skin biopsies of patients with CV associated with severe bacterial infecinfection. No other histopathological findings help us to establish the presence of a severe underlying infection.
Fuente: Clinical and Experimental Rheumatology, 2016, 34(S97), S93-S97
Publisher: Clinical and Experimental Rheumatology
Year of publication: 2016
No. of pages: 5
Publication type: Article
ISSN: 0392-856X,1593-098X
Citations in Google Scholar
JAVIER LORICERA GARCIA
MARIA CARMEN GONZALEZ VELA
RICARDO BLANCO ALONSO
JOSE LUIS HERNANDEZ HERNANDEZ
SUSANA ARMESTO ALONSO
MARCOS ANTONIO GONZALEZ LOPEZ
CALVO RÍO, VANESA
ORTIZ SANJUÁN, F.
JOSE FERNANDO VAL BERNAL
MARIA SANDRA HERMANA RAMIREZ
ARANTZA ONAINDIA PEREZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON
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