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Abstract: Magnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.
Fuente: Small, 2019, 15, 1902626
Publisher: Wiley-VCH Verlag
Publication date: 01/08/2019
No. of pages: 12
Publication type: Article
DOI: 10.1002/smll.201902626
ISSN: 1613-6810,1613-6829
Spanish project: MAT2017-83631-C3
Publication Url: https://doi.org/10.1002/smll.201902626
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GANDIA, DAVID
GANDARIAS, LUCÍA
RODRIGO, IRATI
ROBLES GARCIA, JOSHUA
DAS, RAJA
GARAIO, ENEKO
GARCÍA, JOSÉ ÁNGEL
PHAN, MANH-HUONG
SRIKANTH, HARIHARAN
ORUE, IÑAKI
JAVIER ALONSO MASA
MUELA, ALICIA
FERNÁNDEZ GUBIEDA, MARÍA LUISA
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