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Abstract: The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ?35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
Fuente: British Journal of Haematology, 2019, 186(2), 263-268
Publisher: Blackwell Publishing Ltd
Year of publication: 2019
No. of pages: 6
Publication type: Article
DOI: 10.1111/bjh.15887
ISSN: 0007-1048,1365-2141
Publication Url: https://www.doi.org/10.1111/bjh.15887
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RIBERA, JORDI
GRANADA, ISABEL
MORGADES, MIREIA
VIVES, SUSANA
GENESCÁ, EULALIA
GONZÁLEZ, CELIA
NOMDEDEU, JOSEP
ESCODA, LOURDES
MONTESINOS PAU
MERCADAL, SANTIAGO
COLL, ROSA
GONZÁLEZ-CAMPOS, JOS É
ABELLA, EUGENIA
BARBA, PERE
MARIA ARANZAZU BERMUDEZ RODRIGUEZ
GIL, CRISTINA
TORMO, MAR
PEDREÑO, MARÍA
MARTÍNEZ- CARBALLEIRA, DANIEL
HERNÁNDEZ- RIVAS, JESÚS-MARÍA
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