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Urinary CXCL10 specifically relates to HLA-DQ eplet mismatch load in kidney transplant recipients

Abstract: Background: Urinary CXCL10 (uCXCL10) is associated with graft inflammation and graft survival, but the factors related to its excretion are not well known. HLA molecular matching at epitope level allow estimating the "dissimilarity" between donor and recipient HLA more precisely, being better related to further transplant outcomes. The relationship between uCXCL10 and HLA molecular mismatch has not been previously explored. Methods: HLA class I and class II typing of some 65 recipients and their donors was retrospectively performed by high resolution sequence-specific-primer (Life Technologies, Brown Deer, WI). The HLA-Matchmaker 3.1 software was used to assess eplet matching. Urine samples collected on the day of the 1-year surveillance biopsy were available of these 65 patients. uCXCL10 was measured using a commercial enzyme-linked immunoassay kit. Results: 1-year uCXCL10 was independently associated with HLA-DQB1 eplet mismatch load (b 0.300, 95%CI 0.010-0.058, p = 0.006). Kidney transplant recipients with a HLA-DQB1 eplet mismatch load >3 showed higher values of uCXCL10 at 1-year (p = 0.018) than those with < = 3. Patients with a HLA-DQB1 eplet mismatch load >3 with subclinical AbMR had significantly higher levels of the logarithm of 1-year uCXCL10 (No AbMR 0.88, IQR 0.37; AbMR 1.38, IQR 0.34, p = 0.002) than those without AbMR. Conclusions: uCXCL10 specifically relates to HLA-DQ eplet mismatch load. This relationship can partly explain the previously reported association between uCXCL10 excretion and graft inflammation. An adequate evaluation of any potential non-invasive biomarker, such as uCXCL10, must take into account the HLA molecular mismatch.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Transplant Immunology, Volume 70, February 2022, 101494

Editorial: Elsevier

 Fecha de publicación: 01/02/2022

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.trim.2021.101494

ISSN: 0966-3274,1878-5492

Url de la publicación: https://doi.org/10.1016/j.trim.2021.101494

Autores/as

SAN SEGUNDO, DAVID

GUIRAL FOZ, SANDRA A.

BENITO HERNÁNDEZ, ADALBERTO

RENALDO FERNÁNDEZ, ANDRÉ

ARNAU, ALVARO

VALERO, ROSALÍA

RAMOS BARRÓN, MARÍA ANGELES

MARIA TERESA GARCIA UNZUETA

GÓMEZ ORTEGA, JOSÉ MARÍA

RUIZ, JUAN CARLOS