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Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores

Abstract: Background: There is still uncertainty regarding the role of perioperative chemotherapy (CTx) in patients with resectable colorectal liver metastases (CRLM), especially in those with a low-risk of recurrence. Methods: Multicentre retrospective analysis of patients with CRLM undergoing liver resection between 2010-2015. Patients were divided into two groups according to whether they received perioperative CTx or not and were compared using propensity score matching (PSM) analysis. Then, they were stratified according to prognostic risk scores, including: Clinical Risk Score (CRS), Tumour Burden Score (TBS) and Genetic And Morphological Evaluation (GAME) score. Results: The study included 967 patients with a median follow-up of 68 months. After PSM analysis, patients with perioperative CTx presented prolonged overall survival (OS) in comparison with the surgery alone group (82.8 vs 52.5 months, p = 0.017). On multivariable analysis perioperative CTx was an independent predictor of increased OS (HR 0.705, 95%CI 0.705-0.516, p = 0.029). The benefits of perioperative CTx on survival were confirmed in patients with CRS and TBS scores ?2 (p = 0.022 and p = 0.020, respectively) and in patients with a GAME score ?1 (p = 0.006). Conclusion: Perioperative CTx demonstrated an increase in OS in patients with CRLM. Patients with a low-risk of recurrence seem to benefit from systemic treatment.

 Fuente: HPB (Oxford) . 2021 Dec;23(12):1873-1885

Editorial: Elsevier

 Año de publicación: 2021

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.hpb.2021.04.026

ISSN: 1365-182X,1477-2574

Url de la publicación: https://doi.org/10.1016/j.hpb.2021.04.026

Autores/as

DI MARTINO, MARCELLO

PRIMAVESI, FLORIAN

SYN, NICHOLAS

DORCARATTO, DIMITRI

DE LA HOZ RODRÍGUEZ, ÁNGELA

DUPRÉ, AURÉLIEN

PIARDI, TULLIO

RHAIEM, RAMI

BLANCO FERNÁNDEZ, GERARDO

PRADA VILLAVERDE, ARANCHA

ROBERTO FERNANDEZ SANTIAGO

FERNÁNDEZ-MORENO, MARÍA-CARMEN

FERRET, GEORGINA

LÓPEZ BEN, SANTIAGO

SUÁREZ MUÑOZ, MIGUEL Á

PEREZ-ALONSO, ALEJANDRO J

KOH, YE-XIN

JONES, ROBERT

MARTÍN-PÉREZ, ELENA