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Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

Abstract: The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60?81 years) and 3656 (58.3%; 95% confidence interval 57.1?59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients? profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.

 Fuente: International Journal of Antimicrobial Agents 58 (2021) 106352

Editorial: Elsevier

 Fecha de publicación: 01/07/2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1016/j.ijantimicag.2021.106352

ISSN: 0924-8579,1872-7913

Proyecto español: PI16/01432; RD16/0016/0001; RD16/0016/0008

Url de la publicación: https://doi.org/10.1016/j.ijantimicag.2021.106352

Autores/as

MARTÍNEZ PÉREZ-CRESPO, MARÍA

LANZ-GARCÍA, JOAQUÍN FELIPE

BRAVO-FERRER, JOSÉ

CANTÓN-BULNES, MARÍA LUISA

SOUSA DOMÍNGUEZ, ADRIAN

GOIKOETXEA AGUIRRE, JOSUNE

REGUERA-IGLESIAS, JOSÉ MARÍA

LEÓN JIMÉNEZ, EVA

CARLOS ARMIÑANZAS CASTILLO

MANTECÓN VALLEJO, MARÍA ÁNGELES

MARRODAN CIORDIA, TERESA

FERNÁNDEZ SUÁREZ, JONATHAN

BOIX-PALOP, LUCÍA

CUQUET PEDRAGOSA, JORDI

JOVER SAENZ, ALFREDO

SEVILLA BLANCO, JUAN

GALÁN-SÁNCHEZ, FÁTIMA

NATERA KINDELÁN, CLARA

DEL ARCO JIMÉNEZ, ALFONSO