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Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals

Abstract: The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has been demonstrated to provide a 95% efficacy in naive individuals, the effects of the second vaccine dose in individuals who have previously recovered from natural SARS-CoV-2 infection has not been investigated in detail. In this study, we characterize SARS-CoV-2 spike-specific humoral and cellular immunity in naive and previously infected individuals during and after two doses of BNT162b2 vaccination. Our results demonstrate that, while the second dose increases both the humoral and cellular immunity in naive individuals, COVID-19 recovered individuals reach their peak of immunity after the first dose. These results suggests that a second dose, according to the current standard regimen of vaccination, may be not necessary in individuals previously infected with SARS-CoV-2.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Cell Rep . 2021 Aug 24;36(8):109570

Editorial: Cell Press Elsevier

 Año de publicación: 2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.celrep.2021.109570

ISSN: 2211-1247

Url de la publicación: https://doi.org/10.1016/j.celrep.2021.109570

Autores/as

LOZANO-OJALVO, DANIEL

CAMARA, CARMEN

LOPEZ-GRANADOS, EDUARDO

NOZAL, PILAR

DEL PINO-MOLINA, LUCÍA

BRAVO-GALLEGO, LUZ YADIRA

PAZ-ARTAL, ESTELA

PION, MARJORIE

CORREA-ROCHA, RAFAEL

ORTIZ, ALBERTO

IRIBARREN, MARTA ERRO

PORTOLES, JOSE

ROJO-PORTOLES, MARIA PILAR

OJEDA, GLORIA

CERVERA, ISABEL

GONZALEZ-PEREZ, MARIA

BODEGA-MAYOR, IRENE

MONTES-CASADO, MARIA

PORTOLES, PILAR