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Acinetobacter baumannii and A. pittii clinical isolates lack adherence and cytotoxicity to lung epithelial cells in vitro

Abstract: The molecular and genetic basis of Acinetobacter baumannii and Acinetobacter pittii virulence remains poorly understood, and there is still lack of knowledge in host cell response to these bacteria. In this study, we have used eleven clinical Acinetobacter strains (A. baumannii n = 5; A. pittii n = 6) to unravel bacterial adherence, invasion and cytotoxicity to human lung epithelial cells. Our results showed that adherence to epithelial cells by Acinetobacter strains is scarce and cellular invasion was not truly detected. In addition, all Acinetobacter strains failed to induce any cytotoxic effect on A549 cells.

 Fuente: Microbes and Infection. Volume 18, Issue 9, September 2016, Pages 559-564

Editorial: Elsevier

 Año de publicación: 2016

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

DOI: 10.1016/j.micinf.2016.05.002

ISSN: 1286-4579,1769-714X

Autores/as

LÁZARO DÍEZ, MARÍA

NAVASCUÉS LEJARZA, TERESA

REMUZGO MARTÍNEZ, SARA

LUIS MARTINEZ MARTINEZ

RAMOS VIVAS, JOSÉ