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Influence of gray level and space discretization on brain tumor heterogeneity measures obtained from magnetic resonance images

Abstract: Purpose: Tumor heterogeneityinmedicalimagingisacurrentresearchtrendduetoitspotentialre- lationship withtumormalignancy.Theaimofthisstudyistoanalyzetheeffectofdynamicrangeand matrix sizechangesontheresultsofdifferentheterogeneitymeasures. Materials andmethods: Four patientsharboringthreeglioblastomasandonemetastasiswereconsidered. Sixteen texturalheterogeneitymeasureswerecomputedforeachpatient,withaconfiguration including co-occurrence matrices(CM)features(localheterogeneity)andrun-lengthmatrices(RLM)features (regional heterogeneity).Thecoefficient ofvariationmeasuredagreementbetweenthetexturalmea- sures intwotypesofexperiments:(i) fixing thematrixsizeandchangingthedynamicrangeand(ii) fixing thedynamicrangeandchangingthematrixsize. Results: None ofthemeasuresconsideredwererobustunderdynamicrangechanges.TheCMEntropy and theRLMhighgray-levelrunemphasis(HGRE)weretheoutstandingtexturalfeaturesduetotheir robustness undermatrixsizechanges.Also,theRLMlowgray-levelrunemphasis(LGRE)providedrobust results whenthedynamicrangeconsideredwassufficiently high(morethan8levels).Allofthere- maining texturalfeatureswerenotrobust. Conclusion: Tumor texturestudiesbasedonimageswithdifferentcharacteristics(e.g.multi-center studies) should first fix thedynamicrangetobeconsidered.Forstudiesinvolvingimagesofdifferent resolutions either(i)onlyrobustmeasuresshouldbeused(inourstudyCMentropy,RLMHGREand/or RLM LGRE)or(ii)imagesshouldberesampledtomatchthoseofthelowestresolutionbeforecomputing the texturalfeatures.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Computers in Biology and Medicine Volume 78, 1 November 2016, Pages 49-57

Editorial: Elsevier

 Año de publicación: 2016

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.compbiomed.2016.09.011

ISSN: 0010-4825,1879-0534

Autores/as

MOLINA, DAVID

PÉREZ BETETA, JULIÁN

MARTÍNEZ GONZÁLEZ, ALICIA

CARLOS JOSE VELASQUEZ RODRIGUEZ

ARANA, ESTANISLAO

PÉREZ GARCÍA, VÍCTOR M.