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Glioblastoma: does the pre-treatment geometry matter? A postcontrast T1 MRI-based study

Abstract: Background The potential of a tumour?s volumetric measures obtained from pretreatment MRI sequences of glioblastoma (GBM) patients as predictors of clinical outcome has been controversial. Mathematical models of GBM growth have suggested a relation between a tumour?s geometry and its aggressiveness. Methods A multicenter retrospective clinical study was designed to study volumetric and geometrical measures on pretreatment postcontrast T1 MRIs of 117 GBM patients. Clinical variables were collected, tumours segmented, and measures computed including: contrast enhancing (CE), necrotic, and total volumes; maximal tumour diameter; equivalent spherical CE width and several geometric measures of the CE ?rim?. The significance of the measures was studied using proportional hazards analysis and Kaplan-Meier curves. Results Kaplan-Meier and univariate Cox survival analysis showed that total volume [p = 0.034, Hazard ratio (HR)= 1.574], CE volume (p = 0.017, HR= 1.659), spherical rim width (p =0.007, HR= 1.749), and geometric heterogeneity (p = 0.015, HR= 1.646) were significant parameters in terms of overall survival (OS). Multivariable Cox analysis for OS provided the later two parameters as age-adjusted predictors of OS (p = 0.043, HR = 1.536 and p = 0.032, HR=1.570, respectively). Conclusion Patients with tumours having small geometric heterogeneity and/or spherical rim widths had significantly better prognosis. These novel imaging biomarkers have a strong individual and combined prognostic value for GBM patients.

 Fuente: Eur Radiol (2017) 27:1096-1104

Editorial: Springer

 Año de publicación: 2017

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s00330-016-4453-9

ISSN: 0938-7994,1432-1084

Autores/as

PÉREZ BETETA, JULIÁN

MARTÍNEZ GONZÁLEZ, ALICIA

MOLINA, DAVID

AMO SALAS, MARIANO

LUQUE, BELÉN

ARREGUI, ELENA

CALVO, MANUEL

BORRÁS, JOSÉ M.

LÓPEZ, CARLOS

CLARAMONTE, MARTA

BARCIA, JUAN A.

IGLESIAS, LIDIA

AVECILLAS, JOSUÉ

ALBILLO, DAVID

NAVARRO, MIGUEL

VILLANUEVA, JOSÉ M.

PANIAGUA, JUAN C.

CARLOS JOSE VELASQUEZ RODRIGUEZ

ASENJO, BEATRIZ