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Significant sE-Selectin levels reduction after 6 months of anti-TNF-? therapy in non-diabetic patients with moderate-to-severe psoriasis

Abstract: Purpose: Psoriasis patients have high risk of atherosclerosis, characterized by endothelial dysfunction. We aimed to study the association of the endothelial activation biomarkers monocyte chemoattractant protein 1 (MCP-1), soluble (s) E-selectin and P-selectin with disease activity and severity in psoriasis patients treated with anti-TNF-a therapy. Also, to evaluate the relationship of metabolic syndrome features with these biomarkers and the effect of anti-TNF-a therapy on these molecules. Methods: Twenty-nine consecutive non-diabetic patients with moderate-to-severe psoriasis who underwent 6 months of anti-TNF-a-adalimumab therapy were studied. Metabolic and clinical evaluation was performed prior to anti-TNF-a treatment (time 0) and 6 months later. MCP-1, sE-selectin and sP-selectin serum levels were determined by ELISA. Results: Dyslipidemic and obese patients showed higher MCP-1 levels at month 6 from the onset of anti-TNF-a therapy (p¼.05 and .01, respectively). sE-selectin positively correlated with pro-inflammatory molecules such as asymmetric dimethylarginine, sP-selectin and resistin at baseline and month 6 (p<.05). sE-selectin levels significantly reduced after 6 months of therapy (p¼.0006). Conclusions: Metabolic syndrome features are associated with endothelial activation in patients with moderate-to-severe psoriasis. Adalimumab therapy led to a reduction in sE-selectin levels, supporting the beneficial effect of anti-TNF-a therapy on mechanisms associated with the development of atherosclerosis in psoriasis.

 Fuente: J Dermatolog Treat. 2017 Dec;28(8):726-730

Editorial: Informa Healthcare

 Año de publicación: 2017

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1080/09546634.2017.1329498

ISSN: 0954-6634,1471-1753

Autores/as

FERNANDA GENRE

ALFONSO FERNANDO CORRALES MARTINEZ

LÓPEZ MEJÍAS, RAQUEL

REMUZGO MARTÍNEZ, SARA

PINA MURCIA, TRINITARIO

BEGOÑA UBILLA GARCIA

VERONICA MIJARES DIAZ

MARTÍN VARILLAS, JOSÉ LUIS

JAVIER RUEDA GOTOR

PORTILLA, VIRGINIA

RICARDO BLANCO ALONSO